Optic Nerve Assessment Using 7-Tesla Magnetic Resonance Imaging

Purpose: The purpose of this study was to correlate highresolution magnetic resonance imaging (MRI) and histologic findings in a case of juxtapapillary choroidal melanoma with clinical evidence of optic nerve invasion. Methods: With institutional review board approval, an enucleated globe with choroidal melanoma and optic nerve invasion was imaged using a 7-tesla MRI followed by histopathologic evaluation. Results: Optical coherence tomography, B-scan ultrasonography, and 1.5-tesla MRI of the orbit (1-mm sections) could not detect optic disc invasion. Ex vivo, 7-tesla MRI detected optic nerve invasion, which correlated with histopathologic features. Conclusions: Our case demonstrates the potential to document the existence of optic nerve invasion in the presence of an intraocular tumor, a feature that has a major bearing on decision making, particularly for consideration of enucleation. © 2016 S. Karger AG, Basel Received: October 1, 2015 Accepted after revision: December 8, 2015 Published online: January 27, 2016 Arun D. Singh, MD Department of Ophthalmic Oncology, Cole Eye Institute Cleveland Clinic, 9500 Euclid Ave, I32 Cleveland, OH 44118 (USA) E-Mail singha @ ccf.org © 2016 S. Karger AG, Basel 2296–4681/16/0023–0178$39.50/0